Gas Chromatography Mass Spectrometry (GC-MS)

Last Updated: May 25, 2018

Definition - What does Gas Chromatography Mass Spectrometry (GC-MS) mean?

Gas Chromatography Mass Spectrometry (GC/MS) is a common scientific analytical method for determining individual substances within a sample. Within the context of drug testing, GS/MS is utilized to verify what substances are found within an employee's sample (blood or urine). Gas Chromatography Mass Spectrometry (GC/MS), is considered the gold standard in determining what drug and at what concentration is within a donor’s sample. GC/MS is commonly used as a confirmatory test of other, less expensive, types of drug testing methods, such as immunoassay testing, because GC/MS is highly reliable and capable of being upheld in a court of law.

WorkplaceTesting explains Gas Chromatography Mass Spectrometry (GC-MS)

GC/MS is performed by the use of two machines; a Gas Chromatograph, that is able to separate different substances within a test sample, and a Mass spectrometry, which is used to determine what the specific substances are by plotting them into a spectral plot display and comparing them to know substances. GC/MS is commonly used in drug testing, manufacturing quality control, environmental testing, and even in fire investigations. GC-MS is often implemented after standard drug testing yields positive results of a drug metabolite and further testing necessitates cellular identification of the chemical compound using comparative measurements to support the initial screen results.

This definition was written in the context of Drug Testing
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