Limit of Quantitation


Definition - What does Limit of Quantitation mean?

The limit of quantitation, in terms of drug testing, describes the smallest amount of a drug analyte that can reliably and consistently be detected and measured. Although amounts may be detected in concentrations that are below the limit of quantitation, these readings may be subject to imprecision and bias, and are thus considered unreliable.

WorkplaceTesting explains Limit of Quantitation

The limit of quantitation differs from the limit of detection in that the limit of detection describes the smallest concentration of a drug analyte that can be observed, whereas the limit of quantitation describes the smallest concentration of a drug analyte that not only can be observed, but can also be observed and measured with consistent accuracy, without being subject to imprecision or bias. Therefore, the limit of quantitation of a drug analyte can be expected to be a greater concentration than the limit of detection.

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