Tissue Factor (TF)

Definition - What does Tissue Factor (TF) mean?

Tissue factor (TF) is a receptor protein. When tissue factor is activated by a specific molecule, it initiates what is referred to as the coagulation cascade. This coagulation cascade is a series of signals that cause the blood to clot in response to an injury. Tissue factor is also instrumental in triggering the body's response to inflammation. Tissue factor is found in almost all the cells of the body but is particularly prevalent in blood platelets.

Tissue factor is also referred to as platelet tissue factor, factor III or thromboplastin.

WorkplaceTesting explains Tissue Factor (TF)

Tissue factor (TF) is essential to the process of blood coagulation. Researchers have found that individuals suffering from certain cancers are susceptible to thrombosis (the formation of blood clots). Additionally, studies have indicated that tissue factor affects the development of cancer tumors, their growth rates and metastasis (the spread). Tissue factor is also associated with cardiovascular disease. For these reasons, scientists are investigating the possibility of modifying tissue factor proteins in order to treat cancer and other conditions.

A tissue factor blood test may be performed to assess whether an individual has either abnormally high or low levels of TF.

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